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The intercepts in the right panel were −6.62 (primary cohort) and −2.99 (secondary cohort).

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These intercepts include all other covariate effects evaluated at their mean values.

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JAMAJAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Cumulative incidence of sustained 3-step or more progression from the level of retinopathy present at 18 months for those with and those without 3-step or more early worsening. Probability of early worsening defined as 3-step or more progression (left) and soft exudates/intraretinal microvascular abnormalities (right) in the intensive treatment group for the primary (dashed line) and the secondary (solid line) cohorts as a function of the month 4 to 5 average reduction in hemoglobin A) level from the level at screening estimated from the logistic regression models (adjusted for the mean values of other covariates) in Table 8.


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